ITK/TRKA-IN-1
ITK/TRKA-IN-1 is a dual inhibitor of IL-2-inducible T-cell kinase (ITK) and tropomyosin receptor kinase A (TRKA) with an IC50 value of 1.0 nM and 96 % inhibition, respectively.
Product Specifications
CAS Number
[2655557-54-1]
UNSPSC
12352005
Target
Itk
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/itk-trka-in-1.html
Solubility
10 mM in DMSO
Smiles
C[C@@]12CC3=C(C(C4=NC5=C(N4)C=C(C(N(C([C@@H](N6CCOCC6)C)=O)C)=C5)C)=NN3)C[C@@H]1C2(F)F
Molecular Formula
C25H30F2N6O2
Molecular Weight
484.54
References & Citations
[1]Bagley SW, et al. Benzimidazole Derivatives. WO2021124155A1.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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