KVI-020
KVI-020 is an orally active, potent and selective blocker of the atrial potassium channel Kv1.5, with an IC50 of 480 nM. KVI-020 can inhibits hERG, with an IC50 of 15100 nM. KVI-020 is a potent antiarrhythmic agent, and can be used for atrial fibrillation (AF) research[1].
Product Specifications
CAS Number
1000306-34-2
Product Name Alternative
WYE-160020
UNSPSC
12352005
Target
Potassium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/kvi-020.html
Solubility
10 mM in DMSO
Smiles
O=C1N([C@@](C(C=C2)=CC=C2OC)([H])CN1N[S](C)(=O)=O)CCC(C=C3)=CC=C3OC
Molecular Formula
C20H25N3O5S
Molecular Weight
419.49
References & Citations
[1]Blass BE, et al. Selective Kv1.5 blockers: development of (R) -1- (methylsulfonylamino) -3-[2- (4-methoxyphenyl) ethyl]-4- (4-methoxyphenyl) -2-imidazolidinone (KVI-020/WYE-160020) as a potential treatment for atrial arrhythmia. J Med Chem. 2009 Nov 12;52 (21) :6531-4.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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