KVI-020

KVI-020 is an orally active, potent and selective blocker of the atrial potassium channel Kv1.5, with an IC50 of 480 nM. KVI-020 can inhibits hERG, with an IC50 of 15100 nM. KVI-020 is a potent antiarrhythmic agent, and can be used for atrial fibrillation (AF) research[1].

Product Specifications

CAS Number

[1000306-34-2]

Product Name Alternative

WYE-160020

UNSPSC

12352005

Target

Potassium Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/kvi-020.html

Solubility

10 mM in DMSO

Smiles

O=C1N([C@@](C(C=C2)=CC=C2OC)([H])CN1N[S](C)(=O)=O)CCC(C=C3)=CC=C3OC

Molecular Formula

C20H25N3O5S

Molecular Weight

419.49

References & Citations

[1]Blass BE, et al. Selective Kv1.5 blockers: development of (R) -1- (methylsulfonylamino) -3-[2- (4-methoxyphenyl) ethyl]-4- (4-methoxyphenyl) -2-imidazolidinone (KVI-020/WYE-160020) as a potential treatment for atrial arrhythmia. J Med Chem. 2009 Nov 12;52 (21) :6531-4.