(S,S)-BMS-984923
Product Specifications
UNSPSC Description
(S,S)-BMS-984923 is a less active (S,S)-enantiomer of BMS-984923. (S,S)-BMS-984923 shows an EC50 >1μM for mGluR5 receptor[1]. BMS-984923 is a potent mGluR5 silent allosteric modulator[2]. (S,S)-BMS-984923 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
Target Antigen
mGluR
Type
Reference compound
Related Pathways
GPCR/G Protein;Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/s-s-bms-984923.html
Purity
98.82
Solubility
10 mM in DMSO
Smiles
ClC1=C(C=CC=C1)[C@@]2([H])[C@@](C3=CN=CC(C#CC4=CC=CC=C4)=C3)([H])NC(O2)=O
Molecular Weight
374.82
References & Citations
[1]Andrew P. Degnan, et al. Oxazolidinones as modulators of mglur5. WO2012064603A1.|[2]Laura T Haas, et al. Silent Allosteric Modulation of mGluR5 Maintains Glutamate Signaling while Rescuing Alzheimer's Mouse Phenotypes. Cell Rep. 2017 Jul 5;20(1):76-88.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-141848A/S-S-BMS-984923-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-141848A/S-S-BMS-984923-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
1375752-77-4
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