MMV666810
Product Specifications
UNSPSC Description
MMV666810, a 2-aminopyrazine similar to MMV390048, is potent against asexual parasites at 5.94 nM, but against gametocytes, it has a 3.3-fold selectivity to late-stage gametocytes compared to earlier stages (early-stage gametocyte: IC50 603 ± 88 nM; late-stage gametocyte: IC50 179 ± 8 nM).
Target Antigen
Parasite
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/mmv666810.html
Solubility
10 mM in DMSO
Smiles
O=C(N1CCC(O)CC1)C(C=C2)=CC=C2C3=CN=C(N)C(C4=CC=C(C(F)(F)F)C=C4)=N3
Molecular Weight
442.43
References & Citations
[1]Niemand J, et al. Chemogenomic Fingerprints Associated with Stage-Specific Gametocytocidal Compound Action against Human Malaria Parasites. ACS Infect Dis. 2021 Oct 8;7(10):2904-2916.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-141836/MMV666810-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-141836/
Clinical Information
No Development Reported
CAS Number
1450666-97-3
Curated Selection
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