MMV666810

MMV666810, a 2-aminopyrazine similar to MMV390048, is potent against asexual parasites at 5.94 nM, but against gametocytes, it has a 3.3-fold selectivity to late-stage gametocytes compared to earlier stages (early-stage gametocyte: IC50 603 ± 88 nM; late-stage gametocyte: IC50 179 ± 8 nM) .

Product Specifications

CAS Number

[1450666-97-3]

UNSPSC

12352005

Target

Parasite

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/mmv666810.html

Solubility

10 mM in DMSO

Smiles

O=C(N1CCC(O)CC1)C(C=C2)=CC=C2C3=CN=C(N)C(C4=CC=C(C(F)(F)F)C=C4)=N3

Molecular Formula

C23H21F3N4O2

Molecular Weight

442.43

References & Citations

[1]Niemand J, et al. Chemogenomic Fingerprints Associated with Stage-Specific Gametocytocidal Compound Action against Human Malaria Parasites. ACS Infect Dis. 2021 Oct 8;7 (10) :2904-2916.