MTOR/HDAC-IN-1

MTOR/HDAC-IN-1 (Compound 50) is a selective mTOR and HDAC dual inhibitor with IC50 values of 0.49 and 0.91 nM against mTOR and HDAC1, respectively. mTOR/HDAC-IN-1 can be studied as an anti-cancer agent[1].

Product Specifications

CAS Number

[2815286-02-1]

UNSPSC

12352005

Target

HDAC; mTOR

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Epigenetics; PI3K/Akt/mTOR

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/mtor-hdac-in-1.html

Solubility

10 mM in DMSO

Smiles

NC1=C(C(C2=CC=C(OC(N)=N3)C3=C2)=N4)C(N4CC(CC5)CCN5C6=NC=C(C(NO)=O)C=N6)=NC=N1

Molecular Formula

C23H23N11O3

Molecular Weight

501.50

References & Citations

[1]Mingming Zhang, et al. Discovery of novel pyrazolopyrimidine derivatives as potent mTOR/HDAC bi-functional inhibitors via pharmacophore-merging strategy. Bioorg Med Chem Lett. 2021 Oct 1;49:128286.