MK-886 (sodium salt)
MK-886 (L 663536) sodium salt is a potent, cell-permeable and orally active FLAP (IC50 of 30 nM) and leukotriene biosynthesis (IC50s of 3 nM and 1.1 μM in intact leukocytes and human whole blood, respectively) inhibitor. MK-886 sodium salt is also a non-competitive PPARα antagonist and can induce apoptosis[1][2][3].
Product Specifications
CAS Number
118427-55-7
Product Name Alternative
L 663536 (sodium salt)
UNSPSC
12352005
Target
Apoptosis; FLAP; Leukotriene Receptor; PPAR
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; GPCR/G Protein; Immunology/Inflammation; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/mk-886-sodium-salt.html
Solubility
10 mM in DMSO
Smiles
O=C(C(C)(CC1=C(C2=C(N1CC3=CC=C(C=C3)Cl)C=CC(C(C)C)=C2)SC(C)(C)C)C)O[Na]
Molecular Formula
C27H33ClNNaO2S
Molecular Weight
494.06
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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