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MK-886 (sodium salt)

MK-886 (L 663536) sodium salt is a potent, cell-permeable and orally active FLAP (IC50 of 30 nM) and leukotriene biosynthesis (IC50s of 3 nM and 1.1 μM in intact leukocytes and human whole blood, respectively) inhibitor. MK-886 sodium salt is also a non-competitive PPARα antagonist and can induce apoptosis[1][2][3].

Product Specifications

CAS Number

118427-55-7

Product Name Alternative

L 663536 (sodium salt)

UNSPSC

12352005

Target

Apoptosis; FLAP; Leukotriene Receptor; PPAR

Type

Reference compound

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; GPCR/G Protein; Immunology/Inflammation; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/mk-886-sodium-salt.html

Solubility

10 mM in DMSO

Smiles

O=C(C(C)(CC1=C(C2=C(N1CC3=CC=C(C=C3)Cl)C=CC(C(C)C)=C2)SC(C)(C)C)C)O[Na]

Molecular Formula

C27H33ClNNaO2S

Molecular Weight

494.06

References & Citations

[1]Kehrer JP et al. Inhibition of peroxisome-proliferator-activated receptor (PPAR) alpha by MK886. Biochem J. 2001 Jun 15.|[2]Gillard J et al. L-663,536 (MK-886) (3-[1- (4-chlorobenzyl) -3-t-butyl-thio-5-isopropylindol-2-yl]-2,2 - dimethylpropanoic acid), a novel, orally active leukotriene biosynthesis inhibitor. Can J Physiol Pharmacol. 1989 May;67 (5) :456-64.|[3]Mancini JA, et al. 5-Lipoxygenase-activating protein is the target of a novel hybrid of two classes of leukotriene biosynthesis inhibitors. Mol Pharmacol. 1992 Feb;41 (2) :267-72.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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