(S, R, S) -AHPC-C3-COOH
(S, R, S) -AHPC-C3-COOH (compound 28i) is a carboxylic acid derivative of the VHL E3 ubiquitin ligase ligand-Linker conjugate. (S, R, S) -AHPC-C3-COOH can be used to synthesize PROTACs[1].
Product Specifications
CAS Number
2172819-73-5
UNSPSC
12352005
Hazard Statement
H302-H315-H319
Target
E3 Ligase Ligand-Linker Conjugates
Type
Reference compound
Related Pathways
PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/s-r-s-ahpc-c3-cooh.html
Solubility
10 mM in DMSO
Smiles
OC(CCCC(N[C@@H](C(C)(C)C)C(N1[C@@H](C[C@H](C1)O)C(NCC2=CC=C(C3=C(N=CS3)C)C=C2)=O)=O)=O)=O
Molecular Formula
C27H36N4O6S
Molecular Weight
544.66
Precautions
P264-P270-P280-P302+P352-P330-P362+P364-P501
References & Citations
[1]Zhao Q, et al. Discovery of SIAIS178 as an Effective BCR-ABL Degrader by Recruiting Von Hippel-Lindau (VHL) E3 Ubiquitin Ligase. J Med Chem. 2019 Oct 24;62 (20) :9281-9298.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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