(S, R, S) -AHPC-C3-COOH

(S, R, S) -AHPC-C3-COOH (compound 28i) is a carboxylic acid derivative of the VHL E3 ubiquitin ligase ligand-Linker conjugate. (S, R, S) -AHPC-C3-COOH can be used to synthesize PROTACs[1].

Product Specifications

CAS Number

[2172819-73-5]

UNSPSC

12352005

Hazard Statement

H302-H315-H319

Target

E3 Ligase Ligand-Linker Conjugates

Type

Reference compound

Related Pathways

PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/s-r-s-ahpc-c3-cooh.html

Solubility

10 mM in DMSO

Smiles

OC(CCCC(N[C@@H](C(C)(C)C)C(N1[C@@H](C[C@H](C1)O)C(NCC2=CC=C(C3=C(N=CS3)C)C=C2)=O)=O)=O)=O

Molecular Formula

C27H36N4O6S

Molecular Weight

544.66

Precautions

P264-P270-P280-P302+P352-P330-P362+P364-P501

References & Citations

[1]Zhao Q, et al. Discovery of SIAIS178 as an Effective BCR-ABL Degrader by Recruiting Von Hippel-Lindau (VHL) E3 Ubiquitin Ligase. J Med Chem. 2019 Oct 24;62 (20) :9281-9298.