Pseudouridine 5'-triphosphate (trisodium) solution (100mM)

Pseudouridine 5'-triphosphate (Pseudo-UTP) trisodium solution (100 mM) is a modified ribonucleoside triphosphate. Pseudouridine 5'-triphosphate trisodium solution (100 mM) is substituted for UTP to improve the stability and translation efficiency of mRNA and reduce immunogenicity[1][2][3][4].

Product Specifications

Product Name Alternative

Pseudo-UTP (trisodium) solution (100mM)

UNSPSC

12352005

Target

DNA/RNA Synthesis

Type

Oligonucleotides

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/pseudouridine-5-triphosphate-trisodium.html

Concentration

100 mM * 100 μL in Water

Purity

98.0

Solubility

10 mM in DMSO

Smiles

O=P(O)(O[Na])OP(OP(OC[C@H]1O[C@@H](C(C(N2)=O)=CNC2=O)[C@H](O)[C@@H]1O)(O[Na])=O)(O[Na])=O

Molecular Formula

C9H12N2Na3O15P3

Molecular Weight

550.09

References & Citations

[1]Muthian Shanmugasundaram, et al. An Efficient Protection-Free One-Pot Chemical Synthesis of Modified Nucleoside-5'-Triphosphates. Nucleosides Nucleotides Nucleic Acids. 2016 Jul 2;35 (7) :356-62. |[2]Steinle H, et al. Incorporation of Synthetic mRNA in Injectable Chitosan-Alginate Hybrid Hydrogels for Local and Sustained Expression of Exogenous Proteins in Cells. Int J Mol Sci. 2018 Apr 27;19 (5) :1313. |[3]Golombek S, et al. Intradermal Delivery of Synthetic mRNA Using Hollow Microneedles for Efficient and Rapid Production of Exogenous Proteins in Skin. Mol Ther Nucleic Acids. 2018 Jun 1;11:382-392.|[4]Khan A, et al. Pseudouridine in RNA: enzymatic synthesis mechanisms and functional roles in molecular biology. Int. J. Environ. Agric. Biotechnol, 2023, 8: 284-300.