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(R) -GNE-274

(R) -GNE-274 is a enantiomer of GNE-274. GNE-274 is a non-degrader that is structurally related to GDC-0927 (estrogen receptor degrader) [1].

Product Specifications

UNSPSC

12352005

Target

Drug Isomer

Type

Reference compound

Related Pathways

Others

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/r-gne-274.html

Solubility

10 mM in DMSO

Smiles

CCCN1CC(C1)COC2=CC=C([C@H]3OC4=CC=C(C=C4C(C)=C3C5=CC(O)=CC=C5)O)C=C2

Molecular Formula

C29H31NO4

Molecular Weight

457.56

References & Citations

[1]Guan J, et al. Therapeutic Ligands Antagonize Estrogen Receptor Function by Impairing Its Mobility. Cell. 2019 Aug 8;178 (4) :949-963.e18.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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