MMP145
MMP145 (compound 27) is a potent, selective and orally active MMP-12 inhibitor. MMP145 is effective in inflammation and asthma reasearch[1].
Product Specifications
CAS Number
1025717-75-2
UNSPSC
12352005
Target
MMP
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/mmp145.html
Solubility
10 mM in DMSO
Smiles
CC(C)[C@@H](C(O)=O)NS(=O)(C1=CC=C(C2=CC(N3C(OCC3)=O)=CC=C2O4)C4=C1)=O
Molecular Formula
C20H20N2O7S
Molecular Weight
432.45
References & Citations
[1]Wei Li, Jianchang Li, Yuchuan Wu, Fabio Rancati, Stefania Vallese, Luca Raveglia , Junjun Wu , Rajeev Hotchandani, Nathan Fuller, Kristina Cunningham , Paul Morgan , Susan Fish, Rustem Krykbaev , Xin Xu , Steve Tam , Samuel J. Goldman , William Abraham , Cara Williams, Joseph Sypek and Tarek S.Mansour.Identification of an Orally Efficacious Matrix Metalloprotease 12 Inhibitor for Potential Treatment of AsthmaJ. Med. Chem., 2009, 52 (17), pp 5408–5419.|[2]Li W, et, al. Identification of an orally efficacious matrix metalloprotease 12 inhibitor for potential treatment of asthma. J Med Chem. 2009 Sep 10;52 (17) :5408-19.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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