Cisapride (monohydrate)

Cisapride monohydrate is an orally and potent 5-HT4 receptor agonist and hERG inhibitor. Cisapride monohydrate is an prokinetic agent which facilitates or restores motility throughout the length of the gastrointestinal tract. Cisapride monohydrate stimulates gastrointestinal motor activity through an indirect mechanism involving the release of acetylcholine mediated by postganglionic nerve endings in the myenteric plexus of the gut[1][2].

Product Specifications

CAS Number

[260779-88-2]

Product Name Alternative

R 51619 (monohydrate) ; (±) -Cisaprid (monohydrate)

UNSPSC

12352005

Hazard Statement

H318

Target

5-HT Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/cisapride-monohydrate.html

Solubility

10 mM in DMSO

Smiles

ClC1=C(N)C=C(OC)C(C(N[C@H]2[C@@H](OC)CN(CCCOC3=CC=C(F)C=C3)CC2)=O)=C1.O

Molecular Formula

C23H31ClFN3O5

Molecular Weight

483.96

Precautions

P280-P305+P351+P338

References & Citations

[1]Wiseman, L.R., Faulds, D. Cisapride. Drugs 47, 116–152 (1994) .|[2]Toga T, et al. The 5-HT (4) agonists cisapride, mosapride, and CJ-033466, a Novel potent compound, exhibit different human ether-a-go-go-related gene (hERG) -blocking activities. J Pharmacol Sci. 2007 Oct;105 (2) :207-10.