A-77636
A-77636 is an orally active, potent, selective and long-acting dopamine D1 receptor agonist (pEC50 = 8.13; EC50 = 1.1 nM) . A-77636 shows the highest affinity (pKi = 7.40 ± 0.09; Ki = 39.8 nM) for the dopamine D1 receptor. A-77636 shows antiparkinsonian activity[1].
Product Specifications
CAS Number
778546-51-3
UNSPSC
12352005
Target
Dopamine Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/a-77636.html
Solubility
10 mM in DMSO
Smiles
NC[C@@H]1O[C@H](C2(C[C@@H]3C4)C[C@H](C3)C[C@H]4C2)CC5=C(O)C(O)=CC=C51
Molecular Formula
C20H27NO3
Molecular Weight
329.43
References & Citations
[1]Kebabian JW, et al. A-77636: a potent and selective dopamine D1 receptor agonist with antiparkinsonian activity in marmosets. Eur J Pharmacol. 1992 Dec 15;229 (2-3) :203-9. |[2]Chausmer AL, et al. Comparison of interactions of D1-like agonists, SKF 81297, SKF 82958 and A-77636, with cocaine: locomotor activity and drug discrimination studies in rodents. Psychopharmacology (Berl) . 2002 Jan;159 (2) :145-53.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
D1 Receptor
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
MBS9015782 Inquire
Rabbit anti-Caenorhabditis elegans vab-15 Polyclonal Antibody
Sign In for Pricing
View Details