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TLR8 agonist 2 (hydrochloride)

TLR8 agonist 2 hydrochloride is a potent and selective TLR8 agonist with an EC50 of 3 nM for human TLR8. TLR8 agonist 2 hydrochloride shows less active against human TLR7 (EC50 of 33.33 μM) [1].

Product Specifications

CAS Number

2412937-65-4

UNSPSC

12352005

Target

Toll-like Receptor (TLR)

Type

Reference compound

Related Pathways

Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/tlr8-agonist-2-hydrochloride.html

Solubility

10 mM in DMSO

Smiles

CCCC[C@@](CC1=NN=CN1)(C)NC2=NC(N)=NC3=C2C=CN=C3.[x].Cl

Molecular Formula

C16H22N8.xHCl

References & Citations

[1]Zhe Cai, et al. Tlr8 agonist. WO2020057604A1.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

TLR7; TLR8

Frequently Asked Questions

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