TLR8 agonist 2 (hydrochloride)
TLR8 agonist 2 hydrochloride is a potent and selective TLR8 agonist with an EC50 of 3 nM for human TLR8. TLR8 agonist 2 hydrochloride shows less active against human TLR7 (EC50 of 33.33 μM) [1].
Product Specifications
CAS Number
[2412937-65-4]
UNSPSC
12352005
Target
Toll-like Receptor (TLR)
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/tlr8-agonist-2-hydrochloride.html
Solubility
10 mM in DMSO
Smiles
CCCC[C@@](CC1=NN=CN1)(C)NC2=NC(N)=NC3=C2C=CN=C3.[x].Cl
Molecular Formula
C16H22N8.xHCl
References & Citations
[1]Zhe Cai, et al. Tlr8 agonist. WO2020057604A1.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
TLR7; TLR8
Curated Selection
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