N-Succinimidyl 3- (Bromoacetamido) propionate

N-Succinimidyl 3- (Bromoacetamido) propionate is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. N-Succinimidyl 3- (Bromoacetamido) propionate is also a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) [2].

Product Specifications

CAS Number

[57159-62-3]

Product Name Alternative

3- (2-Bromoacetamido) propanoic acid NHS ester

UNSPSC

12352203

Hazard Statement

H315-H319-H335

Target

ADC Linker; PROTAC Linkers

Type

ADC Related

Related Pathways

Antibody-drug Conjugate/ADC Related; PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/n-succinimidyl-3-bromoacetamido-propionate.html

Solubility

10 mM in DMSO

Smiles

O=C(ON1C(CCC1=O)=O)CCNC(CBr)=O

Molecular Formula

C9H11BrN2O5

Molecular Weight

307.10

Precautions

P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

References & Citations

[1]An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.|[2]Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16 (5) :315-337.