BMS-665053

BMS-665053 is a corticotropin-releasing factor-1 (CRF1) receptor antagonist (IC50 = 1.0 nM) . BMS-665053) 11 is a potent inhibitor of CRF-stimulated cyclic adenosine monophosphate (cAMP) production in human Y-79 retinoblastoma cells (IC50 = 4.9 nM) [1].

Product Specifications

CAS Number

[1173435-64-7]

UNSPSC

12352005

Target

CRFR

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/bms-665053.html

Solubility

10 mM in DMSO

Smiles

ClC1=CN([C@H](C2CC2)C)C(C(NC3=C(Cl)C=C(OC(F)F)C=C3Cl)=N1)=O

Molecular Formula

C16H14Cl3F2N3O2

Molecular Weight

424.66

References & Citations

[1]Jianqing Li, et al. An Efficient, Direct Bis-ortho-chlorination of 4- (Difluoromethoxy) aniline and Its Application to the Synthesis of BMS-665053, a Potent and Selective Pyrazinone-Containing Corticotropin-Releasing Factor-1 Receptor Antagonist. Organic Process Research & Development, 16, 156-159.