TCO-PEG4-TCO

TCO-PEG4-TCO is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1]. TCO-PEG4-TCO is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.

Product Specifications

CAS Number

[2243569-23-3]

UNSPSC

12352211

Hazard Statement

H302-H315-H319-H335

Target

PROTAC Linkers

Type

Reference compound

Related Pathways

PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/tco-peg4-tco.html

Solubility

10 mM in DMSO

Smiles

O=C(OC1CC/C=C\CCC1)NCCOCCOCCOCCOCCNC(OC2CC/C=C\CCC2)=O

Molecular Formula

C28H48N2O8

Molecular Weight

540.69

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

References & Citations

[1]Wang Y, et al. Degradation of proteins by PROTACs and other strategies. Acta Pharm Sin B. 2020 Feb;10 (2) :207-238.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

PEG Linkers

Curated Selection

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