TCO-PEG3-amide-C3-triethoxysilane

TCO-PEG3-amide-C3-triethoxysilane is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. TCO-PEG3-amide-C3-triethoxysilane is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.

Product Specifications

CAS Number

[2250217-32-2]

UNSPSC

12352211

Hazard Statement

H302-H315-H319-H335

Target

PROTAC Linkers

Type

Reference compound

Related Pathways

PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/tco-peg3-amide-c3-triethoxysilane.html

Solubility

10 mM in DMSO

Smiles

CCO[Si](OCC)(OCC)CCCNC(CCOCCOCCOCCNC(OC1CCC/C=C\CC1)=O)=O

Molecular Formula

C27H52N2O9Si

Molecular Weight

576.80

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

References & Citations

[1]An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562