(S) -TCO-PEG3-amine
(S) -TCO-PEG3-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. (S) -TCO-PEG3-amine is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.
Product Specifications
UNSPSC
12352211
Hazard Statement
H302-H315-H319-H335
Target
PROTAC Linkers
Type
Reference compound
Related Pathways
PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/s-tco-peg3-amine.html
Solubility
10 mM in DMSO
Smiles
O=C(O[C@H]1CCC/C([H])=C/CC1)NCCOCCOCCOCCN
Molecular Formula
C17H32N2O5
Molecular Weight
344.45
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
[1]An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PEG Linkers
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