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TCO-PEG2-Sulfo-NHS ester (sodium)

TCO-PEG2-Sulfo-NHS ester sodium is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. TCO-PEG2-Sulfo-NHS ester (sodium) is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.

Product Specifications

UNSPSC

12352005

Target

PROTAC Linkers

Type

Reference compound

Related Pathways

PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/tco-peg2-sulfo-nhs-ester-sodium.html

Solubility

10 mM in DMSO

Smiles

O=C(ON1C(C(S(=O)(O[Na])=O)CC1=O)=O)CCOCCOCCNC(OC2CC/C=C\CCC2)=O

Molecular Formula

C20H29N2NaO11S

Molecular Weight

528.51

References & Citations

[1]An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

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