TCO-PEG2-Sulfo-NHS ester (sodium)
TCO-PEG2-Sulfo-NHS ester sodium is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. TCO-PEG2-Sulfo-NHS ester (sodium) is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.
Product Specifications
UNSPSC
12352005
Target
PROTAC Linkers
Type
Reference compound
Related Pathways
PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/tco-peg2-sulfo-nhs-ester-sodium.html
Solubility
10 mM in DMSO
Smiles
O=C(ON1C(C(S(=O)(O[Na])=O)CC1=O)=O)CCOCCOCCNC(OC2CC/C=C\CCC2)=O
Molecular Formula
C20H29N2NaO11S
Molecular Weight
528.51
References & Citations
[1]An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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