TCO-PEG12-acid
Product Specifications
UNSPSC Description
TCO-PEG12-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1]. TCO-PEG12-acid is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.
Target Antigen
PROTAC Linkers
Type
Reference compound
Related Pathways
PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/tco-peg12-acid.html
Solubility
10 mM in DMSO
Smiles
O=C(O)CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCNC(OC1CC/C=C\CCC1)=O
Molecular Weight
769.91
References & Citations
[1]Wang Y, et al. Degradation of proteins by PROTACs and other strategies. Acta Pharm Sin B. 2020 Feb;10(2):207-238.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-141162/TCO-PEG12-acid-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-141162/
Clinical Information
No Development Reported
Curated Selection
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