TCO-PEG8-acid

TCO-PEG8-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1]. TCO-PEG8-acid is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.

Product Specifications

CAS Number

[2353410-03-2]

UNSPSC

12352211

Hazard Statement

H302-H315-H319-H335

Target

PROTAC Linkers

Type

Reference compound

Related Pathways

PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/tco-peg8-acid.html

Solubility

10 mM in DMSO

Smiles

O=C(OC1CC/C=C\CCC1)NCCOCCOCCOCCOCCOCCOCCOCCOCCC(O)=O

Molecular Formula

C28H51NO12

Molecular Weight

593.70

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

References & Citations

[1]Wang Y, et al. Degradation of proteins by PROTACs and other strategies. Acta Pharm Sin B. 2020 Feb;10 (2) :207-238.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

PEG Linkers

Curated Selection

Explore Other Products

Discover premium biology products from our extensive collection of 20M+ items

TL318917V 500 µL Each

RPL36AL Human shRNA Lentiviral Particle (Locus ID 6166)

Ask

View Details

MBS9005125 Inquire

Rabbit anti-Encephalitozoon cuniculi (strain GB-M1)(Microsporidian parasite) ECU11_1980 Polyclonal Antibody

Ask

View Details

MBS1261301-01 0.02 mg (E-Coli)

Recombinant Human immunodeficiency virus type 2 subtype A Protein Tat (tat)

Ask

View Details

MBS1261301-02 0.1 mg (E-Coli)

Recombinant Human immunodeficiency virus type 2 subtype A Protein Tat (tat)

Ask

View Details

MBS1261301-03 0.02 mg (Yeast)

Recombinant Human immunodeficiency virus type 2 subtype A Protein Tat (tat)

Ask

View Details

MBS1261301-04 0.1 mg (Yeast)

Recombinant Human immunodeficiency virus type 2 subtype A Protein Tat (tat)

Ask

View Details