N- (Iodoacetamido) -Doxorubicin
N- (Iodoacetamido) -Doxorubicin is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) [1].
Product Specifications
CAS Number
[114390-30-6]
UNSPSC
12352203
Hazard Statement
H302-H315-H319-H335
Target
ADC Linker
Type
ADC Related
Related Pathways
Antibody-drug Conjugate/ADC Related
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/n-iodoacetamido-doxorubicin.html
Solubility
10 mM in DMSO
Smiles
COC1=CC=CC2=C1C(C3=C(C2=O)C(O)=C4C([C@@H](O[C@@H]5O[C@@H](C)[C@@H](O)[C@@H](NC(CI)=O)C5)C[C@@](C(CO)=O)(O)C4)=C3O)=O
Molecular Formula
C29H30INO12
Molecular Weight
711.45
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
[1]Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16 (5) :315-337.
Shipping Conditions
Room temperature
Scientific Category
ADC Related
Clinical Information
No Development Reported
Isoform
Cleavable Linker
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