7-O- (Cbz-N-amido-PEG4) -paclitaxel

7-O- (Cbz-N-amido-PEG4) -paclitaxel is a PEG-class Drug-linker conjugates for ADC, containing a paclitaxel moiety and a amino group. The amine group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. 7-O- (Cbz-N-amido-PEG4) -paclitaxel can be used in the synthesis of Antibody-Drug Conjugates (ADCs) [1].

Product Specifications

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

Drug-Linker Conjugates for ADC

Type

Reference compound

Related Pathways

Antibody-drug Conjugate/ADC Related

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/7-o-cbz-n-amido-peg4-paclitaxel.html

Solubility

10 mM in DMSO

Smiles

CC1=C([C@@H](OC(C)=O)C([C@@]2(C)C([C@@](CO3)(OC(C)=O)[C@H]3C[C@@H]2OC(CCOCCOCCOCCOCCNC(OCC4=CC=CC=C4)=O)=O)[C@@H]5OC(C6=CC=CC=C6)=O)=O)C(C)(C)[C@@]5(O)C[C@@H]1OC([C@H](O)[C@@H](NC(C7=CC=CC=C7)=O)C8=CC=CC=C8)=O

Molecular Formula

C66H78N2O21

Molecular Weight

1235.33

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562