Carboxyrhodamine 110-PEG3-Azide

Carboxyrhodamine 110-PEG3-Azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Carboxyrhodamine 110-PEG3-Azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

Product Specifications

CAS Number

[1536327-95-3]

UNSPSC

12352005

Hazard Statement

H315-H319-H335

Target

PROTAC Linkers

Type

Reference compound

Related Pathways

PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/carboxyrhodamine-110-peg3-azide.html

Solubility

10 mM in DMSO

Smiles

[O-]C(C1=CC(C(NCCOCCOCCOCCN=[N+]=[N-])=O)=CC=C1C2=C(C=CC(N)=C3)C3=[O+]C4=C2C=CC(N)=C4)=O.[O-]C(C5=CC=C(C(NCCOCCOCCOCCN=[N+]=[N-])=O)C=C5C6=C(C=CC(N)=C7)C7=[O+]C8=C6C=CC(N)=C8)=O

Molecular Formula

C29H30N6O7

Molecular Weight

574.60

Precautions

P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

References & Citations

[1]An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562