N- (m-PEG4) -N'- (DBCO-PEG4) -Cy5

N- (m-PEG4) -N'- (DBCO-PEG4) -Cy5 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. N- (m-PEG4) -N'- (DBCO-PEG4) -Cy5 is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

Product Specifications

CAS Number

[2107273-76-5]

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

PROTAC Linkers

Type

Reference compound

Related Pathways

PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/n-m-peg4-n-dbco-peg4-cy5.html

Solubility

10 mM in DMSO

Smiles

COCCOCCOCCOCC[N+]1=C(/C=C/C=C/C=C2N(CCOCCOCCOCCOCCC(NCCC(N3C4=CC=CC=C4C#CC5=CC=CC=C5C3)=O)=O)C6=C(C=CC=C6)C/2(C)C)C(C)(C)C7=C1C=CC=C7.[Cl-]

Molecular Formula

C63H79ClN4O10

Molecular Weight

1087.78

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562