N- (azide-PEG3) -N'- (Amine-C3-Amide-PEG4) -Cy5

N- (azide-PEG3) -N'- (Amine-C3-Amide-PEG4) -Cy5 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. N- (azide-PEG3) -N'- (Amine-C3-Amide-PEG4) -Cy5 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

Product Specifications

CAS Number

[2107273-70-9]

UNSPSC

12352005

Target

PROTAC Linkers

Type

Reference compound

Related Pathways

PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/n-azide-peg3-n-amine-c3-amide-peg4-cy5.html

Solubility

10 mM in DMSO

Smiles

CC1(C)C(/C=C/C=C/C=C2N(CCOCCOCCOCCOCCC(NCCCN)=O)C3=C(C=CC=C3)C/2(C)C)=[N+](CCOCCOCCOCCN=[N+]=[N-])C4=C1C=CC=C4.[Cl-]

Molecular Formula

C47H70ClN7O8

Molecular Weight

896.55

References & Citations

[1]An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562