N,N'-bis-(azide-PEG3)-Cy5

Product Specifications

CAS Number

[2107273-46-9]

UNSPSC Description

NN'-bis-(azide-PEG3)-Cy5 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. N,N'-bis-(azide-PEG3)-Cy5 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

Target Antigen

PROTAC Linkers

Type

Dye Reagents

Related Pathways

PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/n-n-bis-azide-peg3-cy5.html

Solubility

10 mM in DMSO

Smiles

CC1(C)C(/C=C/C=C/C=C2N(CCOCCOCCOCCN=[N+]=[N-])C3=C(C=CC=C3)C/2(C)C)=[N+](CCOCCOCCOCCN=[N+]=[N-])C4=C1C=CC=C4.[Cl-]

Molecular Weight

793.39

References & Citations

[1]An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562