N-methyl-N'-methyl-O- (m-PEG4) -O'- (propargyl-PEG4) -Cy5

N-methyl-N'-methyl-O- (m-PEG4) -O'- (propargyl-PEG4) -Cy5 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. N-methyl-N'-methyl-O- (m-PEG4) -O'- (propargyl-PEG4) -Cy5 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Product Specifications

CAS Number

[2107273-50-5]

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

PROTAC Linkers

Type

Reference compound

Related Pathways

PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/n-methyl-n-methyl-o-m-peg4-o-propargyl-peg4-cy5.html

Solubility

10 mM in DMSO

Smiles

C#CCOCCOCCOCCOCCOC1=CC2=C(C=C1)[N+](C)=C(C2(C)C)/C=C/C=C/C=C3N(C4=C(C\3(C)C)C=C(C=C4)OCCOCCOCCOCCOC)C.[Cl-]

Molecular Formula

C47H67ClN2O10

Molecular Weight

855.50

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562