N-PEG3-N'- (propargyl-PEG4) -Cy5

N-PEG3-N'- (propargyl-PEG4) -Cy5 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. N-PEG3-N'- (propargyl-PEG4) -Cy5 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Product Specifications

CAS Number

[2107273-06-1]

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

PROTAC Linkers

Type

Reference compound

Related Pathways

PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/n-peg3-n-propargyl-peg4-cy5.html

Solubility

10 mM in DMSO

Smiles

CC1(C)C(/C=C/C=C/C=C2N(CCOCCOCCOCCOCC#C)C3=C(C=CC=C3)C/2(C)C)=[N+](CCOCCOCCO)C4=C1C=CC=C4.[Cl-]

Molecular Formula

C42H57ClN2O7

Molecular Weight

737.36

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562