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N- (Azido-PEG4) -N-bis (PEG4-NHS ester)

N- (Azido-PEG4) -N-bis (PEG4-NHS ester) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. N- (Azido-PEG4) -N-bis (PEG4-NHS ester) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

Product Specifications

CAS Number

2353409-90-0

UNSPSC

12352005

Target

PROTAC Linkers

Type

Reference compound

Related Pathways

PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/n-azido-peg4-n-bis-peg4-nhs-ester.html

Solubility

10 mM in DMSO

Smiles

O=C(CCOCCOCCOCCOCCN(CCOCCOCCOCCOCCC(ON(C1=O)C(CC1)=O)=O)C(CCOCCOCCOCCOCCN=[N+]=[N-])=O)ON(C2=O)C(CC2)=O

Molecular Formula

C41H68N6O21

Molecular Weight

981.01

References & Citations

[1]An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

PEG Linkers

Available Sizes

Frequently Asked Questions

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