Azide-PEG-azide (MW 20000)

Azide-PEG-azide (MW 20000) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Azide-PEG-azide (MW 20000) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

Product Specifications

UNSPSC

12352211

Target

PROTAC Linkers

Type

Reference compound

Related Pathways

PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/azide-peg-azide-mw-20000.html

Solubility

10 mM in DMSO

Smiles

[N-]=[N+]=NCCOCCN=[N+]=[N-].[n].[MW20000]

Molecular Weight

20000 (Average)

References & Citations

[1]An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562