N-Desthiobiotin-N-bis (PEG4-NHS ester)
N-Desthiobiotin-N-bis (PEG4-NHS ester) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Product Specifications
CAS Number
[2353409-61-5]
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
PROTAC Linkers
Type
Reference compound
Related Pathways
PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/n-desthiobiotin-n-bis-peg4-nhs-ester.html
Solubility
10 mM in DMSO
Smiles
O=C(CCOCCOCCOCCOCCN(CCOCCOCCOCCOCCC(ON(C1=O)C(CC1)=O)=O)C(CCCCC[C@@H](NC2=O)[C@@H](N2)C)=O)ON(C3=O)C(CC3)=O
Molecular Formula
C40H65N5O18
Molecular Weight
903.97
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
[1]An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PEG Linkers
Available Sizes
Curated Selection
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