N- (DBCO-PEG4) -N-Biotin-PEG4-NHS

N- (DBCO-PEG4) -N-Biotin-PEG4-NHS is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. N- (DBCO-PEG4) -N-Biotin-PEG4-NHS is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

Product Specifications

CAS Number

[2353409-72-8]

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

PROTAC Linkers

Type

Reference compound

Related Pathways

PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/n-dbco-peg4-n-biotin-peg4-nhs.html

Solubility

10 mM in DMSO

Smiles

O=C(ON1C(CCC1=O)=O)CCOCCOCCOCCOCCN(C(CCCC[C@@H]2SC[C@]([C@]2([H])N3)([H])NC3=O)=O)CCOCCOCCOCCOCCNC(CCC(N4C5=CC=CC=C5C#CC6=CC=CC=C6C4)=O)=O

Molecular Formula

C54H74N6O16S

Molecular Weight

1095.26

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

References & Citations

[1]An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562