N- (Acid-PEG2) -N-bis (PEG3-azide)

N- (Acid-PEG2) -N-bis (PEG3-azide) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. N- (Acid-PEG2) -N-bis (PEG3-azide) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

Product Specifications

CAS Number

[2320560-35-6]

UNSPSC

12352211

Hazard Statement

H302-H315-H319-H335

Target

PROTAC Linkers

Type

Reference compound

Related Pathways

PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/n-acid-peg2-n-bis-peg3-azide.html

Purity

98.0

Solubility

10 mM in DMSO

Smiles

O=C(CCOCCOCCC(O)=O)N(CCOCCOCCOCCN=[N+]=[N-])CCOCCOCCOCCN=[N+]=[N-]

Molecular Formula

C24H45N7O11

Molecular Weight

607.65

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

References & Citations

[1]An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562