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N- (Azido-PEG3) -N-bis (PEG4-acid)

N- (Azido-PEG3) -N-bis (PEG4-acid) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. N- (Azido-PEG3) -N-bis (PEG4-acid) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

Product Specifications

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H335

Target

PROTAC Linkers

Type

Reference compound

Related Pathways

PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/n-azido-peg3-n-bis-peg4-acid.html

Purity

98.0

Solubility

10 mM in DMSO

Smiles

O=C(O)CCOCCOCCOCCOCCN(CCOCCOCCOCCN=[N+]=[N-])CCOCCOCCOCCOCCC(O)=O

Molecular Formula

C30H58N4O15

Molecular Weight

714.80

Precautions

H302, H315, H319, H335

References & Citations

[1]An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, protect from light)

Product Datasheet

http://file.medchemexpress.com/batch_PDF/HY-140518/N-Azido-PEG3-N-bis-PEG4-acid-DataSheet-MedChemExpress.pdf

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-140518/N-Azido-PEG3-N-bis-PEG4-acid-SDS-MedChemExpress.pdf

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

PEG Linkers

CAS Number

[2112731-54-9]

Available Sizes

Curated Selection

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