N- (Azido-PEG3) -N-bis (PEG3-acid)

N- (Azido-PEG3) -N-bis (PEG3-acid) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. N- (Azido-PEG3) -N-bis (PEG3-acid) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

Product Specifications

CAS Number

[2055042-57-2]

UNSPSC

12352211

Hazard Statement

H302-H315-H319-H335

Target

PROTAC Linkers

Type

Reference compound

Related Pathways

PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/n-azido-peg3-n-bis-peg3-acid.html

Solubility

10 mM in DMSO

Smiles

O=C(O)CCOCCOCCOCCN(CCOCCOCCOCCN=[N+]=[N-])CCOCCOCCOCCC(O)=O

Molecular Formula

C26H50N4O13

Molecular Weight

626.69

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

References & Citations

[1]An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562