AZD-CO-C2-Ph-amido-Ph-azide

AZD-CO-C2-Ph-amido-Ph-azide is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1]. AZD-CO-C2-Ph-amido-Ph-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

Product Specifications

CAS Number

[1383544-71-5]

UNSPSC

12352005

Target

PROTAC Linkers

Type

Reference compound

Related Pathways

PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/azd-co-c2-ph-amido-ph-azide.html

Solubility

10 mM in DMSO

Smiles

O=C(C1=CC=C(C=C1)N=[N+]=[N-])NC2=CC=C(C=C2)CCC(N3CCC3=O)=O

Molecular Formula

C19H17N5O3

Molecular Weight

363.37

References & Citations

[1]An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562