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APN-C3-NH-Boc

APN-C3-NH-Boc is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1]. APN-C3-NH-Boc is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Product Specifications

CAS Number

1539292-60-8

Product Name Alternative

Tert-Butyl 3- (4- (2-cyanoethynyl) phenylcarbamoyl) propylcarbamate

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

PROTAC Linkers

Type

Reference compound

Related Pathways

PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/apn-c3-nh-boc.html

Solubility

10 mM in DMSO

Smiles

O=C(OC(C)(C)C)NCCCC(NC1=CC=C(C#CC#N)C=C1)=O

Molecular Formula

C18H21N3O3

Molecular Weight

327.38

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

Alkyl/ether Linkers

Frequently Asked Questions

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