DBCO-mPEG (MW 10kDa)

DBCO-mPEG (MW 10kDa) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. DBCO-mPEG (MW 10kDa) is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

Product Specifications

UNSPSC

12352005

Target

PROTAC Linkers

Type

Reference compound

Related Pathways

PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/dbco-mpeg-mw-10kda.html

Solubility

10 mM in DMSO

Smiles

O=C(CCC(NCCOCCOC)=O)N1CC2=CC=CC=C2C#CC3=C1C=CC=C3.[n].[MW10kDa]

Molecular Weight

10000 (Average)

References & Citations

[1]An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562