M-PEG8-DBCO
M-PEG8-DBCO is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. m-PEG8-DBCO is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
Product Specifications
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
PROTAC Linkers
Type
Reference compound
Related Pathways
PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/m-peg8-dbco.html
Solubility
10 mM in DMSO
Smiles
O=C(CCC(NCCOCCOCCOCCOCCOCCOCCOCCOC)=O)N1CC2=C(C#CC3=C1C=CC=C3)C=CC=C2
Molecular Formula
C36H50N2O10
Molecular Weight
670.79
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
[1]An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PEG Linkers
Frequently Asked Questions
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