Carboxyrhodamine 110-PEG4-DBCO

Carboxyrhodamine 110-PEG4-DBCO is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Carboxyrhodamine 110-PEG4-DBCO is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

Product Specifications

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

PROTAC Linkers

Type

Reference compound

Related Pathways

PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/carboxyrhodamine-110-peg4-dbco.html

Solubility

10 mM in DMSO

Smiles

[O-]C(C1=C(C2=C3C=CC(C=C3OC4=C2C=CC(N)=C4)=[NH2+])C=C(C(NCCOCCOCCOCCOCCC(NCCC(N5C6=C(C#CC7=C(C5)C=CC=C7)C=CC=C6)=O)=O)=O)C=C1)=O.[O-]C(C8=C(C(C9=C(O%10)C=C(N)C=C9)=C(C=C%11)C%10=CC%11=[NH2+])C=CC(C(NCCOCCOCCOCCOCCC(NCCC(N%12C%13=C(C#CC%14=C(C%12)C=CC=C%14)C=CC=C%13)=O)=O)=O)=C8)=O

Molecular Formula

C50H49N5O10

Molecular Weight

879.97

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562