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DBCO-PEG4-NH-Boc

DBCO-PEG4-NH-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. DBCO-PEG4-NH-Boc is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

Product Specifications

CAS Number

2353410-17-8

UNSPSC

12352005

Hazard Statement

H315-H319-H335

Target

PROTAC Linkers

Type

Reference compound

Related Pathways

PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/dbco-peg4-nh-boc.html

Solubility

10 mM in DMSO

Smiles

O=C(OC(C)(C)C)NCCOCCOCCOCCOCCNC(CCC(N1C2=CC=CC=C2C#CC3=CC=CC=C3C1)=O)=O

Molecular Formula

C34H45N3O8

Molecular Weight

623.74

Precautions

P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

References & Citations

[1]An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

Alkyl/ether Linkers; PEG Linkers

Frequently Asked Questions

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