Fmoc-NH-ethyl-SS-propionic NHS ester

Fmoc-NH-ethyl-SS-propionic NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) [1].

Product Specifications

CAS Number

[2128735-23-7]

UNSPSC

12352203

Hazard Statement

H302-H315-H319-H335

Target

ADC Linker

Type

ADC Related

Related Pathways

Antibody-drug Conjugate/ADC Related

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/fmoc-nh-ethyl-ss-propionic-nhs-ester.html

Solubility

10 mM in DMSO

Smiles

O=C(ON1C(CCC1=O)=O)CCSSCCNC(OCC2C3=C(C4=C2C=CC=C4)C=CC=C3)=O

Molecular Formula

C24H24N2O6S2

Molecular Weight

500.59

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

References & Citations

[1]Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16 (5) :315-337.

Shipping Conditions

Room temperature

Scientific Category

ADC Related

Clinical Information

No Development Reported

Isoform

Cleavable Linker; Disulfide Cleavable Linker

Curated Selection

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