N- (Propargyl-PEG4) -N-bis (PEG4-acid)

N- (Propargyl-PEG4) -N-bis (PEG4-acid) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. N- (Propargyl-PEG4) -N-bis (PEG4-acid) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Product Specifications

CAS Number

[2093153-09-2]

UNSPSC

12352211

Hazard Statement

H302-H315-H319-H335

Target

PROTAC Linkers

Type

Reference compound

Related Pathways

PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/n-propargyl-peg4-n-bis-peg4-acid.html

Solubility

10 mM in DMSO

Smiles

O=C(O)CCOCCOCCOCCOCCN(CCOCCOCCOCCOCC#C)CCOCCOCCOCCOCCC(O)=O

Molecular Formula

C33H61NO16

Molecular Weight

727.83

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

References & Citations

[1]An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

PEG Linkers

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