Azido-PEG3-amide-C3-triethoxysilane

Azido-PEG3-amide-C3-triethoxysilane is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Azido-PEG3-amide-C3-triethoxysilane is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

Product Specifications

CAS Number

[2243566-43-8]

UNSPSC

12352211

Target

PROTAC Linkers

Type

Reference compound

Related Pathways

PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/azido-peg3-amide-c3-triethoxysilane.html

Solubility

10 mM in DMSO

Smiles

O=C(NCCC[Si](OCC)(OCC)OCC)CCOCCOCCOCCN=[N+]=[N-]

Molecular Formula

C18H38N4O7Si

Molecular Weight

450.60

References & Citations

[1]An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562